表观遗传学
染色质
表观基因组
生物
异染色质
基因组编辑
遗传学
计算生物学
基因
基因表达
基因表达调控
清脆的
DNA甲基化
标识
DOI:10.1016/j.tibs.2018.06.001
摘要
The epigenome editing framework provides an engineering approach to explore chromatin-based gene expression mechanisms. However, therapeutic utility of epigenetic editing-based systems has been lacking. A report in Cell (Liu et. al., 2018) shows that epigenetic editors can revert abnormal heterochromatin formation at the gene promoter leading to restoration of FMR1 gene expression, functionally rescuing fragile X syndrome (FXS), an otherwise unamenable genetic disorder.
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