Clinical research of recombinant human brain natriuretic peptide combined with sodium nitroprusside in the treatment of acute decompensated heart failure

Objective To investigate the effects of recombinant human brain natriuretic peptide and sodium nitroprusside in the treatment of acute decompensated heart failure. Methods 82 patients with acute decompensated heart failure were randomly divided into observation group and control group, 41 cases in each group.The control group was given sodium nitroprusside intravenous infusion therapy on the basis of routine treatment.The observation group was given recombinant human brain natriuretic peptide infusion treatment on the basis of control group treatment.The clinical efficacy was compared between the two groups. Results The total effective rate of the observation group was 95.12%, which was significantly higher than 75.61% of the control group (χ2=5.33, P 0.05). Conclusion Recombinant human brain natriuretic peptide combined with sodium nitroprusside could significantly improve the clinical curative effect of acute decompensated heart failure, improve heart function of patients, and inhibit myocardial remodeling.It had good security. Key words: Recombinant human brain natriuretic peptide; Sodium nitroprusside; Acute decompensated heart failure