Research progress of autoimmune encephalitis in children

The immune mechanisms are involved in the pathogenesis of many acute encephalitis and encephalopathies.The discovery of auto-antibodies in the central nervous system promotes the development of neurology.The more common auto-antibody-associated encephalitis syndromes in children include anti- N-methyl-D-aspartate receptor encephalitis, anti- myelin oligodendrocyte glycoprotein antibody associated demyelination, anti- gamma-aminobutyric acid (GABA)-A receptor encephalitis, antiglycine receptor encephalitis, basal ganglia encephalitis and anti- glutamic acid decarboxylase encephalitis.Other auto-antibodies described in adults are very rare or unreported in childhood cases.There is no consensus definition for the diagnosis of seronegative suspected autoimmune encephalitis in pediatrics.This paper reviews the progress of autoimmune encephalitis of children with antibody mediated and serological negative in recent years. Key words: Auto-antibody; Autoimmune; Encephalitis; Child