中性粒细胞胞外陷阱
转移
癌症
医学
肿瘤微环境
癌症研究
免疫学
肿瘤进展
炎症
免疫系统
内科学
作者
Maria Teresa Masucci,Michele Minopoli,Silvana Del Vecchio,Maria Vincenza Carriero
标识
DOI:10.3389/fimmu.2020.01749
摘要
Neutrophil Extracellular Traps (NETs) are net-like structures composed of DNA-histone complexes and proteins released by activated neutrophils. In addition to their key role in the neutrophil innate immune response, NETs are also involved in autoimmune diseases, like systemic lupus erythematosus, rheumatoid arthritis, psoriasis, and in other noninfectious pathological processes, as coagulation disorders, thrombosis, diabetes, atherosclerosis, vasculitis and cancer. Recently, a large body of evidence indicates that NETs are involved in cancer progression and metastatic dissemination, both in animal models and cancer patients. Interestingly, a close correlation between cancer cell recruitment of neutrophils in the tumor microenvironment (Tumor Associated Neutrophils. TANs) and NET formation has been also observed either in primary tumors and metastatic sites. Moreover, NETs are able to catch circulating cancer cells and promote metastasis, as well. Furthermore, NETs have been reported to awake dormant cancer cells, thus causing tumor relapse and metastasis. This review will primarily focus on the pro-tumorigenic activity of NETs in tumors highlighting their ability to serve as potential target for cancer therapy.
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