几丁质酶
甲壳素
昆虫
杀虫剂
生物
糖苷键
生物化学
生物技术
酶
计算生物学
生态学
壳聚糖
标识
DOI:10.1021/acs.jafc.0c00888
摘要
Chitinase (EC 3.2.1.14) is an enzyme to breakdown β-1,4-glycosidic bonds in chitin and chitooligosaccharides. The loss of chitinase enzymatic activity in insects results in severe exoskeleton defects and lethality at all developmental stages, indicating that insect chitinases can be promising pesticide targets. However, there are no pesticides known to target chitinases. This perspective will focus on the latest research progress of insect chitinases, paying special attention to crystal structures and chemical biology advances in the field. The physiological importance and unique structural features of insect chitinases may ensure the development of new pesticides through a novel acting mode.
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