G蛋白偶联胆汁酸受体
效应器
炎症
生物
免疫系统
受体
药理学
细胞生物学
免疫学
生理学
生物化学
作者
Alessia Perino,Kristina Schoonjans
标识
DOI:10.1016/j.tips.2015.08.002
摘要
In the past decade substantial progress has been made in understanding how the insurgence of chronic low-grade inflammation influences the physiology of several metabolic diseases. Tissue-resident immune cells have been identified as central players in these processes, linking inflammation to metabolism. The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages, and its activation mediates potent anti-inflammatory effects. Herein, we summarize recent advances in TGR5 research, focusing on the downstream effector pathways that are modulated by TGR5 activators, and on its therapeutic potential in inflammatory and metabolic diseases.
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