RNA干扰
生物
基因沉默
RNA沉默
计算生物学
生物发生
RNA诱导沉默复合物
核糖核酸
遗传学
反式siRNA
基因
细胞生物学
作者
Jonathan J. Ipsaro,Leemor Joshua‐Tor
摘要
Since its relatively recent discovery, RNA interference (RNAi) has emerged as a potent, specific and ubiquitous means of gene regulation. Through a number of pathways that are conserved in eukaryotes from yeast to humans, small noncoding RNAs direct molecular machinery to silence gene expression. In this Review, we focus on mechanisms and structures that govern RNA silencing in higher organisms. In addition to highlighting recent advances, we discuss parallels and differences among RNAi pathways. Together, the studies reviewed herein reveal the versatility and programmability of RNA-induced silencing complexes and emphasize the importance of both upstream biogenesis and downstream silencing factors.
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