Intracavitary Bacillus Calmette-Guerin in the Treatment of Superficial Bladder Tumors

No AccessJournal of Urology1 Feb 2017Intracavitary Bacillus Calmette-Guerin in the Treatment of Superficial Bladder Tumors A. Morales, D. Eidinger, and A.W. Bruce A. MoralesA. Morales Current address: Laboratory of Immunodiagnosis, Building 8, Room 118, National Institutes of Health, Bethesda, Maryland 20014. More articles by this author , D. EidingerD. Eidinger More articles by this author , and A.W. BruceA.W. Bruce More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.10.101AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Patients with recurrent superficial bladder tumors have been treated by vesical and intradermal administration of Bacillus Calmette-Guerin. The pattern of recurrence in 9 patients has been altered favorably. Although the findings are still preliminary they appear to hold promise of a new therapeutic approach to the treatment of a group of neoplasms for which effective therapy is still lacking. References 1 Veenema, R. J., Dean, A. L., Jr., Uson, A. C., Roberts, M. and Longo, F.: Thiotepa bladder instillations: therapy and prophylaxis for superficial bladder tumors. J. Urol., 101: 711, 1969. Google Scholar 2 Riddle, P. R.: The management of superficial bladder tumors with intravesical epodyl. Brit. J. Urol., 45: 84, 1973. Google Scholar 3 Durrant, K. R. and Laing, A. H.: Treatment of multiple superficial papillary tumors of the bladder by intracavitary yttrium-90. J. Urol., 113: 480, 1975. Google Scholar 4 Bubenik, J., Perlmann, P., Helmstein, K. and Moberger, G. Immune response to urinary bladder tumours in man. Int. J. Cancer, 5: 39, 1970. Google Scholar 5 Catalona, W. J. and Chretien, P. B.: Correlation among host immunocompetence and tumor stage, tumor grade and vascular permeation in transitional carcinoma. J. Urol., 110: 526, 1973. Google Scholar 6 Zbar, B. and Rapp, H. J.: Immunotherapy of guinea pig cancer with BCG. Cancer, 34: 1532, 1974. Google Scholar 7 Jondal, M., Holm, G. and Wigzell, H.: Surface markers on human T and B lymphocytes. I. A large population of lymphocyte forming nonimmune rosettes with sheep red blood cells. J. Exp. Med., 136: 207, 1973. Google Scholar 8 Ferluga, J.: Increased cytolytic activity of a subcellular fraction from mouse liver after B.C.G. injection. Lancet, 2: 1476, 1973. Google Scholar 9 Gutterman, J., Mavligit, G., McBride, C., Frei, E., Ill and Hersh, E. M.: BCG stimulation of immune responsiveness in patients with malignant melanoma. Cancer, 32: 321, 1973. Google Scholar 10 Grant, R. M., Mackie, R., Cochran, A. J., Murray, E. L., Hoyle, D. and Ross, C.: Results of administering B.C.G. to patients with melanoma. Lancet, 2: 1096, 1974. Google Scholar 11 Donaldson, R. C.: Chemoimmunotherapy for cancer of the head and neck. Amer. J. Surg., 126: 507, 1973. Google Scholar 12 Morales, A. and Eidinger, D.: Bacillus Calmette-Guerin in the treatment of adenocarcinoma of the kidney. J. Urol., 115: 37, 1976. Google Scholar 13 Bloomberg, S. D., Brosman, S. A., Hausman, M. S., Cohen, A. and Battenberg, J. D.: The effects of BCG on the dog bladder. Invest. Urol., 12: 423, 1975. Google Scholar 14 Hanna, M. G., Jr., Snodgrass, M. J., Zbar, B. and Rapp, H. J.: Histopathology of Mycobacterium bovis (BCG)-mediated tumor regression. Nat. Cancer Inst. Monogr., 35: 345, 1972. Google Scholar 15 Falk, R. E., Mann, P. and Langer, B.: Cell-mediated immunity to human tumors. Abrogation by serum factors and nonspecific effects of oral BCG therapy. Arch. Surg., 107: 261, 1973. Google Scholar 16 Morales, A. and Eidinger, D.: Immune reactivity in renal cancer a sequential study. J. Urol., 115: 510, 1976. Google Scholar 17 Papatestas, A. E. and Kark, A. E.: Peripheral lymphocyte counts in breast carcinoma. An index of immune competence. Cancer, 34: 2014, 1974. Google Scholar © 2002 by American Urological Association, Inc.®FiguresReferencesRelatedDetails Volume 197Issue 2SFebruary 2017Page: S142-S145 Advertisement Copyright & Permissions© 2002 by American Urological Association, Inc.®MetricsAuthor Information A. Morales Current address: Laboratory of Immunodiagnosis, Building 8, Room 118, National Institutes of Health, Bethesda, Maryland 20014. More articles by this author D. Eidinger More articles by this author A.W. Bruce More articles by this author Expand All Advertisement PDF downloadLoading ...