Mesenchymal stem cell migration in a murine model of myocardial infarction

Aims: Mesenchymal stem cell (MSC)-based therapies are presently under investigation for the treatment of myocardial infarction (MI). However, for MSCs to regenerate the wounded myocardium, tissue specific homing is crucial. We sought out to determine whether amplifying the cytokine signals released by the ischemic myocardium can enhance the recruitment of intravenously (IV) administered bone marrow-derived MSCs.