Preparation of amino acid ester substituted polyphosphazene microparticles via electrohydrodynamic atomization

Abstract This study aims to fabricate biodegradable polyphosphazene microparticles by electrohydrodynamic atomization (EHDA) for applications in drug delivery system. Polyphosphazene microparticles with varied morphologies, such as spherical, doughnut‐shaped, and corrugated, were resulted from electrospraying depending on solvents, molecular weight of polyphosphazene, and concentration of polymeric solution. The solubility of polyphosphazene in different solvents was found to be a significant factor determining the particle‐to‐fiber formation, while concentration of polymeric solution has remarkable effect on particle morphology. Accordingly, a graphic description was proposed to interpret the formation of polyphosphazene microparticles during EHDA. Copyright © 2010 John Wiley & Sons, Ltd.