化学
水解
核磁共振波谱
分解
二甲基亚砜
质子
光谱学
质子核磁共振
戒指(化学)
分子
质子磁共振
核磁共振
光化学
有机化学
量子力学
物理
作者
Gerard P. Moloney,David J. Craik,Magdy N. Iskander
标识
DOI:10.1002/jps.2600810721
摘要
A series of 3,4‐dihydro‐1,3‐benzoxazine and 3,4‐dihydro‐1,3‐pyridooxazine derivatives was synthesized, and the hydrolysis of the derivatives was studied with proton nuclear magnetic resonance spectroscopy. The oxazine derivatives underwent various degrees of hydrolysis when H2O was added to dimethyl sulfoxide solutions of the compounds. The rates and extents of decomposition of the oxazine ring systems depended on the electronic effects of substituents within the molecules. Examination of the proton nuclear magnetic resonance spectra that were generated during decomposition of the oxazines and trends in stability of the oxazine derivatives suggest the formation of an intermediate in the hydrolysis mechanism.
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