血管生成
壁细胞
血管生成
细胞生物学
细胞外基质
动脉发生
功能(生物学)
生物
受体
神经科学
癌症研究
血管平滑肌
干细胞
平滑肌
内分泌学
祖细胞
生物化学
出处
期刊:Nature Medicine
[Springer Nature]
日期:2003-06-01
卷期号:9 (6): 685-693
被引量:2309
摘要
The maturation of nascent vasculature, formed by vasculogenesis or angiogenesis, requires recruitment of mural cells, generation of an extracellular matrix and specialization of the vessel wall for structural support and regulation of vessel function. In addition, the vascular network must be organized so that all the parenchymal cells receive adequate nutrients. All of these processes are orchestrated by physical forces as well as by a constellation of ligands and receptors whose spatio-temporal patterns of expression and concentration are tightly regulated. Inappropriate levels of these physical forces or molecules produce an abnormal vasculature--a hallmark of various pathologies. Normalization of the abnormal vasculature can facilitate drug delivery to tumors and formation of a mature vasculature can help realize the promise of therapeutic angiogenesis and tissue engineering.
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