生物
小RNA
自噬
转移
癌症研究
下调和上调
泛素
癌症
结直肠癌
癌基因
生物标志物
环状RNA
细胞生物学
信号转导
基因
细胞周期
遗传学
细胞凋亡
作者
Feifei Chen,Lei Guo,Jiehui Di,Man Li,Dong Dong,Dong‐Sheng Pei
标识
DOI:10.1016/j.jgg.2021.07.017
摘要
Numerous circular RNAs (circRNAs) have been identified as vital regulators in various cancers. The newly reported circular RNA ubiquitin-associated protein 2 (circUBAP2) is a critical player in cell growth and metastasis in various types of cancers, although its role in colorectal cancer (CRC) has yet to be fully elucidated. We find that circUBAP2 is upregulated in CRC tissues and cell lines to induce autophagy both in vitro and in vivo. The effects of circUBAP2 on migration, invasion, and proliferation may be partially related to autophagy. Mechanistically, we uncover that circUBAP2 can directly interact with miR-582-5p and subsequently act as a microRNA sponge to regulate the expression of the miR-582-5p target gene forkhead box protein O1 (FOXO1) and downstream signaling molecules, which collectively advance the progression and metastasis of CRC. These results suggest that circUBAP2 acts as an oncogene via a novel circUBAP2/miR-582-5p/FOXO1 axis, providing a potential biomarker and therapeutic target for CRC management.
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