乳铁蛋白
PEG比率
聚乙二醇
化学
光热治疗
共轭体系
胶体金
口服
吸收(声学)
癌症研究
体内
生物物理学
药理学
材料科学
医学
纳米颗粒
生物化学
纳米技术
生物
有机化学
复合材料
经济
生物技术
聚合物
财务
作者
Hyung Shik Kim,Seung-Jae Lee,Dong Yun Lee
标识
DOI:10.1016/j.bioactmat.2021.06.026
摘要
Orally absorbable gold nanoparticles (AuNP) having cancer ablation therapy is strongly demanded to treat glioblastoma multiforme (GBM) for patients with its highest incidence rate. Here, we develop a milk protein lactoferrin-conjugated AuNP for its oral absorption and targeting to the GBM through the interaction between lactoferrin (Lf) and lactoferrin receptor (LfR) that is highly expressed in the intestine, blood-brain barrier and GBM. For stability and long circulation of AuNP, glutathione and polyethylene glycol (PEG) is introduced, which is called to Lf-PEG-AuNP. When Lf-PEG-AuNP are orally administered to orthotopic GBM-bearing mice, 11-fold and 8-fold higher concentrations of AuNP are measured in bloodstreams and GBM in the brain, respectively, compared with unconjugated-AuNP. Therefore, orally administered Lf-PEG-AuNP exhibit an outstanding temperature rise in GBM by irradiating laser and significantly reduce tumor volume. Collectively, we suggest that the Lf-PEG-AuNP can fundamentally target GBM in the brain through oral absorption, and that its efficient photothermal therapy is possible.
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