Drug delivery systems for Intra⁃articular injection in the Osteoarthritis treatment

Intra⁃articular injection is one of the most important treatment for osteoarthritis (OA) drug administration. It would improve the pharmacotherapy efficacy and reduce the adverse drug reaction and toxic effect of drugs. In the last decades, the microspheres, nanoparticles, hydrogels, and other drug delivery systems have been extensively studied in OA therapy. This paper reviews the late research development on OA treated via IA drug delivery systems.