卵黄发生
生物
卵黄原蛋白
蛋黄
血淋巴
血粉
中肠
内科学
内分泌学
乌鳢科
卵子发生
滴答声
细胞生物学
动物
生物化学
硬蜱科
病毒学
幼虫
卵母细胞
生态学
基因
胚胎
医学
作者
Meryem Behri,Haruki Teshima,Keisuke Kutsuwada,Shoko Nakatake,Mari H. Ogihara,DeMar Taylor
出处
期刊:Insect Science
[Wiley]
日期:2022-04-03
卷期号:29 (5): 1299-1308
被引量:3
标识
DOI:10.1111/1744-7917.13025
摘要
Initiation of vitellogenesis by blood feeding is essential for egg maturation in ticks. Nutrients derived from the blood meal are utilized by female ticks to synthesize the yolk protein precursor vitellogenin (Vg). Engorged Ornithodoros moubata ticks can synthesize Vg whether mated or virgin, thus O. moubata is an excellent model for studying the relative roles of blood feeding and mating in tick vitellogenesis. Injection of rapamycin into engorged O. moubata resulted in a reduction of ovarian growth and yolk accumulation in the oocytes of mated females. OmVg expression in the midgut and fat body and protein concentrations in the hemolymph significantly decreased in mated ticks after injection with rapamycin, indicating that inhibition of the nutrient-sensing target of rapamycin (TOR) pathway disrupts egg maturation at the levels of Vg expression and synthesis. These results suggest that the TOR-signaling pathway induces vitellogenesis in response to nutritional stimulation after a blood meal in O. moubata and is functionally independent of the mating-induced pathway.
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