沙门氏菌
药物输送
癌症治疗
免疫疗法
免疫系统
药品
细菌
医学
纳米技术
癌症
生物
免疫学
药理学
材料科学
遗传学
内科学
作者
Wenfei Chen,Yining Zhu,Zhirong Zhang,Xun Sun
标识
DOI:10.1016/j.addr.2022.114295
摘要
The clinical application of bacteria-mediated immune therapy dates back over a century ago. In recent years, these strategies have advanced greatly with the rapid development of synthetic biology and nanotechnology. Several bacterial therapies have been developed allowing for more effective treatments for cancers, and Salmonella is one of the most studied bacterial species. Here, we review the advances in the bioengineered and functionalized Salmonella Typhimurium strains as drug delivery carries, including the various genetic circuits for programing these bacteria, the surface modification strategies using nanoparticles or other therapeutic agents for richer and broader features, and the bacterial component-based vehicles for cancer immunotherapy. This review will include the promises and challenges of these optimized Salmonella-based delivery systems and their related clinical trials. Ultimately, we hope to provide a spark of thought in the field of drug delivery and find important crosstalk between bacteria-mediated therapy and other different forms of treatments.
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