牙周纤维
牙周膜干细胞
骨愈合
化学
干细胞
组织工程
细胞生物学
再生医学
体内
再生(生物学)
生物医学工程
解剖
牙科
医学
生物
生物技术
生物化学
碱性磷酸酶
酶
作者
Mingxiang Cai,Yaoyao Liu,Yinping Tian,Yan Liang,Zinan Xu,Fangchen Liu,Renfa Lai,Zhen Zhou,Minyi Liu,Jian Dai,Xiangning Liu
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:10 (7): 1765-1775
被引量:2
摘要
Bone tissue engineering shows great potential in bone regeneration; however, the lack of bone growth factors with high biocompatibility and efficiency is a major concern. Oligopeptides have drawn great attention due to their high biological efficacy, low toxicity, and low molecular weight. The oligopeptide SDSSD promotes the osteogenesis of human periodontal ligament stem cells (hPDLSCs) in vitro. The SDSSD-modified three-dimensional (3D) bioscaffolds promote osteogenesis and bone formation in the subcutaneous pockets of BALB/c nude mice and facilitate bone healing in vivo. Mechanistically, SDSSD promoted bone formation by binding to G protein-coupled receptors and regulating the AKT signaling pathway. 3D-printing bioscaffolds with SDSSD may be potential bone tissue engineering materials for treating bone defects.
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