Longitudinal associations between adolescents’ individualised risk for depression and inflammation in a UK cohort study

重性抑郁障碍 苏帕 医学 队列 社会心理的 内科学 生物标志物 炎症 C反应蛋白 队列研究 萧条(经济学) 临床心理学 尿激酶受体 精神科 心情 纤溶酶原激活剂 生物 生物化学 经济 宏观经济学
作者
Rachel M. Latham,Christian Kieling,Louise Arseneault,Brandon A. Kohrt,Terrie E. Moffitt,Line Jee Hartmann Rasmussen,Thiago Botter-Maio Rocha,Valeria Mondelli,Helen L. Fisher
出处
期刊:Brain Behavior and Immunity [Elsevier BV]
卷期号:101: 78-83 被引量:14
标识
DOI:10.1016/j.bbi.2021.12.027
摘要

Inflammation is associated with poor physical and mental health including major depressive disorder (MDD). Moreover, there is evidence that childhood adversity – a risk factor for MDD – becomes biologically embedded via elevated inflammation. However, the risk of developing MDD arises from multiple sources and yet there has been little investigation of the links between individuals' constellation of MDD risk and subsequent inflammation. We therefore examined associations between individual risk for MDD calculated in early adolescence and levels of inflammation six years later. We use data from the Environmental Risk (E-Risk) Longitudinal Twin Study, a nationally representative UK birth cohort of 2,232 children followed to age 18 with 93% retention. Participants' individual risk for developing future MDD was calculated at age 12 using a recently developed prediction model comprising multiple psychosocial factors. Plasma levels of three inflammation biomarkers were measured at age 18: C-reactive protein (CRP), interleukin-6 (IL-6), and a newer biomarker, soluble urokinase plasminogen activator receptor (suPAR), which is thought to reflect the level of systemic chronic inflammation. MDD risk scores calculated at age 12 were positively associated with levels of suPAR (but not CRP or IL-6) at age 18 after adjusting for key covariates (b = 1.70, 95% CI = 0.46 – 2.95, p = 0.007). Adolescents at high risk of MDD (risk scores ≥ 90th centile) had significantly higher mean levels of suPAR six years later than adolescents who had been identified as low risk (risk scores ≤ 10th centile) (b = 0.41, 95% CI = 0.18 – 0.64, p < 0.001). Findings support the notion that childhood psychosocial risk for MDD leads to increased levels of low-grade inflammation. If replicated in studies with repeated assessments of inflammation biomarkers throughout childhood and adolescence, these findings would support targeted interventions to reduce inflammation, as measured by suPAR, for adolescents at high risk of MDD to potentially prevent development of depression and physical health problems related to chronic inflammation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
铜泰妍完成签到 ,获得积分10
4秒前
2012csc完成签到 ,获得积分0
4秒前
巴啦啦能量完成签到 ,获得积分10
8秒前
madison完成签到 ,获得积分10
10秒前
wwj1009完成签到 ,获得积分10
20秒前
含蓄文博完成签到 ,获得积分10
26秒前
重要的幻然完成签到,获得积分10
27秒前
笨笨青筠完成签到 ,获得积分10
29秒前
跳跃的冷卉完成签到 ,获得积分10
30秒前
如意的馒头完成签到 ,获得积分10
35秒前
哒哒哒哒完成签到,获得积分10
37秒前
飘逸问兰发布了新的文献求助10
43秒前
上官完成签到 ,获得积分10
48秒前
毛哥看文献完成签到 ,获得积分10
52秒前
飘逸问兰完成签到,获得积分10
57秒前
chentong完成签到 ,获得积分10
57秒前
ufofly730完成签到 ,获得积分10
58秒前
SciGPT应助飘逸问兰采纳,获得10
1分钟前
1分钟前
薛微有点甜完成签到 ,获得积分10
1分钟前
开拖拉机的医学僧完成签到 ,获得积分10
1分钟前
轻松的纸鹤完成签到,获得积分10
1分钟前
加贝完成签到 ,获得积分10
1分钟前
zzy发布了新的文献求助10
1分钟前
zhaogl完成签到,获得积分10
1分钟前
1分钟前
JJ完成签到 ,获得积分10
1分钟前
1分钟前
倪小呆完成签到 ,获得积分10
1分钟前
wonwojo完成签到 ,获得积分10
1分钟前
John完成签到 ,获得积分10
1分钟前
eterny完成签到,获得积分10
1分钟前
幸福完成签到 ,获得积分20
1分钟前
xue112完成签到 ,获得积分10
1分钟前
雪儿完成签到 ,获得积分10
1分钟前
firewood完成签到,获得积分10
1分钟前
在水一方应助科研通管家采纳,获得10
1分钟前
cdercder应助科研通管家采纳,获得10
1分钟前
cdercder应助科研通管家采纳,获得10
1分钟前
迈克老狼完成签到 ,获得积分10
1分钟前
高分求助中
Introduction to Strong Mixing Conditions Volumes 1-3 500
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
Optical and electric properties of monocrystalline synthetic diamond irradiated by neutrons 320
共融服務學習指南 300
Essentials of Pharmacoeconomics: Health Economics and Outcomes Research 3rd Edition. by Karen Rascati 300
Peking Blues // Liao San 300
Political Ideologies Their Origins and Impact 13 edition 240
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3800967
求助须知:如何正确求助?哪些是违规求助? 3346553
关于积分的说明 10329541
捐赠科研通 3063068
什么是DOI,文献DOI怎么找? 1681330
邀请新用户注册赠送积分活动 807474
科研通“疑难数据库(出版商)”最低求助积分说明 763721