抗菌活性
涂层
纳米技术
纳米颗粒
材料科学
表面改性
药物输送
抗菌剂
苯扎溴铵
组合化学
化学
化学工程
细菌
有机化学
工程类
遗传学
物理化学
生物
作者
Min Zhang,Feng Jin,Yuening Zhong,Jiangqi Luo,Yuchen Zhao,Yang Yang,Yaping Song,Xinjie Lin,Yannan Yang,Hao Song,Chengzhong Yu
标识
DOI:10.1016/j.cej.2022.135837
摘要
Biomimetic rough silica nanoparticles (RNPs) have emerged as a promising drug delivery platform for antimicrobial applications, featuring unique adhesive property towards pathogens and enabling efficient bacterial killing. However, bare silica has an inert nature, thus requiring post-loading of antimicrobial agents. The in-situ synthesis of bioactive RNPs containing antibacterial agents is highly desired but remains challenging. Herein, we report the designed synthesis of bactericidal RNPs templated by an antibacterial drug of benzalkonium chloride (BAC). Compared to the counterpart with a smooth surface, RNPs-BAC exhibit enhanced antibacterial performance. Moreover, the RNPs-BAC nanocomposites allow ease of functionalization of substrates and fabric masks, providing an antibacterial coating strategy with durable pathogen-killing performance that cannot be achieved by the antibacterial drug itself. This proof-of-concept study demonstrates the potential of the innovative RNPs-based nanocomposites in antibacterial applications such as medical and wearable devices.
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