质谱成像
药品
药物发现
毒性
计算生物学
药物毒性
法医毒理学
毒理
药理学
化学
质谱法
生物
生物信息学
医学
色谱法
内科学
作者
Haiyan Jiang,Shanshan Gao,Guoqing Hu,Jie He,Hongtao Jin
出处
期刊:Toxicology
[Elsevier]
日期:2021-12-01
卷期号:464: 153000-153000
被引量:9
标识
DOI:10.1016/j.tox.2021.153000
摘要
Mass spectrometry imaging (MSI) is a powerful molecular imaging technology that can obtain qualitative, quantitative, and location information by simultaneously detecting and mapping endogenous or exogenous molecules in biological tissue slices without specific chemical labeling or complex sample pretreatment. This article reviews the progress made in MSI and its application in drug toxicology research, including the tissue distribution of toxic drugs and their metabolites, the target organs (liver, kidney, lung, eye, and central nervous system) of toxic drugs, the discovery of toxicity-associated biomarkers, and explanations of the mechanisms of drug toxicity when MSI is combined with the cutting-edge omics methodologies. The unique advantages and broad prospects of this technology have been fully demonstrated to further promote its wider use in the field of pharmaceutical toxicology.
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