伏隔核
脑深部刺激
酒精使用障碍
神经调节
禁欲
神经科学
医学
脑刺激奖励
脑刺激
刺激
上瘾
人体研究
动物研究
心理学
精神科
酒
多巴胺
疾病
生物
内科学
帕金森病
生物化学
作者
Allen L. Ho,Anne-Mary N. Salib,Arjun V Pendharkar,Eric S Sussman,William J. Giardino,Casey H. Halpern
出处
期刊:Neurosurgical Focus
[Journal of Neurosurgery Publishing Group]
日期:2018-08-01
卷期号:45 (2): E12-E12
被引量:17
标识
DOI:10.3171/2018.5.focus18157
摘要
Alcohol use disorder (AUD) is a difficult to treat condition with a significant global public health and cost burden. The nucleus accumbens (NAc) has been implicated in AUD and identified as an ideal target for deep brain stimulation (DBS). There are promising preclinical animal studies of DBS for alcohol consumption as well as some initial human clinical studies that have shown some promise at reducing alcohol-related cravings and, in some instances, achieving long-term abstinence. In this review, the authors discuss the evidence and concepts supporting the role of the NAc in AUD, summarize the findings from published NAc DBS studies in animal models and humans, and consider the challenges and propose future directions for neuromodulation of the NAc for the treatment of AUD.
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