膀胱癌
医学
小RNA
尿
癌症
诊断生物标志物
肿瘤科
内科学
实时聚合酶链反应
泌尿科
基因
生物
遗传学
作者
Leila Nekoohesh,Mohammad Hossein Modarressi,Seyed Javad Mowla,Esmaeil Sadroddiny,Masoud Etemadian,Mandana Afsharpad,Faezeh Zolfaghari,M Barzegari,Mojtaba Saffari,Vahid Kholghi Oskooei,Elahe Motevaseli,Soudeh Ghafouri‐Fard
出处
期刊:Biomarkers in Medicine
[Future Medicine]
日期:2018-12-01
卷期号:12 (12): 1311-1321
被引量:12
标识
DOI:10.2217/bmm-2018-0190
摘要
Aim: miRNAs have been suggested as biomarkers for bladder cancer. We aimed to find a diagnostic panel of miRNAs based on differential expression of miRNAs in urine specimens of patient with bladder cancer compared with control group. Methods: miR-141, miR-10b, miR-34b and miR-103 were selected to assess their expression in urine samples of 66 bladder cancer patients and 53 matched controls using quantitative real time PCR. Results: miR-10b and miR-34b were upregulated in cases compared with controls. The combination of four miRNAs showed a sensitivity of 75% and specificity of 63.5% with a diagnostic power of 72%. Conclusion: Certain miRNAs can be used as biomarkers for early diagnosis of bladder cancer.
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