纳米载体
药物输送
DNA
表皮生长因子受体
化学
癌症研究
药品
纳米技术
药理学
材料科学
医学
受体
生物化学
作者
Tiantian Wu,Jianbing Li,Manman Liu,Shaoli Liu,Shuai Zhao,Run Tian,Dengshuai Wei,Yangzhong Liu,Yao Zhao,Haihua Xiao,Baoquan Ding
标识
DOI:10.1002/anie.201909345
摘要
Abstract The targeted delivery of chemotherapeutic drugs is a major challenge in the clinical treatment of cancer. Herein, we constructed a multifunctional DNA nanoplatform as a versatile carrier of the highly potent platinum‐based DNA intercalator, 56MESS. In our rational design, 56MESS was efficiently loaded into the double‐bundle DNA tetrahedron through intercalation with the DNA duplex. With the integration of a nanobody that both targets and blocks epidermal growth factor receptor (EGFR), the DNA nanocarriers exhibit excellent selectivity for cells with elevated EGFR expression (a common biomarker related to tumor formation) and combined tumor therapy without obvious systemic toxicity. This DNA‐based platinum‐drug delivery system provides a promising strategy for the treatment of tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI