丁酸梭菌
厚壁菌
神经炎症
双歧杆菌
梭菌
神经保护
氟西汀
内科学
粪便
肠道菌群
免疫学
微生物学
小胶质细胞
医学
生物
炎症
药理学
细菌
乳酸菌
血清素
16S核糖体RNA
遗传学
受体
作者
Tian Tian,Bing Xu,Yinhua Qin,Lina Fan,Jianjun Chen,Peng Zheng,Xue Gong,Haiyang Wang,Mengge Bai,Juncai Pu,Jian Lu,Zhou Wei,Libo Zhao,Deyu Yang,Peng Xie
标识
DOI:10.1016/j.bbrc.2019.06.053
摘要
Recent studies have suggested the neuroprotective effects of Clostridium butyricum on mood disorders. However, the potential role of Clostridium butyricum in modulating the gut-brain-axis remains unknown. Here, we applied the commercial Clostridium butyricum Miyairi 588 (CBM588) strain to assess psychological behavioural alterations in mice exposed to chronic social defeat stress (CSDS). We found that preventive treatment with CBM588 for 28 days ameliorated depressive-like behaviours in CSDS mice. We showed that CSDS led to increases in cytokines (IL-1β, IL-6, and TNF-α), intestinal dysfunction and hippocampal microglial activation, while CBM588 partially relieved these alterations. By applying 16S sequencing, we found that Firmicutes was more abundant in the faeces of CBM588/CSDS mice than in the faeces of placebo/CSDS mice, and depression-like behaviours in the mice were correlated with certain strains (including Clostridium leptum, Blautia coccoides, Family_XIII_UCG-001, Candidatus Arthromitus sp-SFB-mouse-Japan and Streptococcus hyointestinalis) at the species level. Our results illustrated the preventive effect of CBM588 against stress, suggesting the beneficial role of CBM588 in regulating neuroinflammation via the gut-brain-axis. This study provides novel strategies for clinical and scientific investigations of depressive disorders.
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