造血
炎症体
GATA1公司
生物
斑马鱼
上睑下垂
免疫学
骨髓
髓样
细胞生物学
Diamond–Blackfan贫血
癌症研究
红细胞生成
炎症
干细胞
医学
贫血
遗传学
基因
内科学
核糖体
核糖核酸
作者
Lola Rodríguez‐Ruiz,Juan M. Lozano-Gil,Christophe Lachaud,Pablo Mesa-del-Castillo,María L. Cayuela,Diana García‐Moreno,Ana B. Pérez-Oliva,Victoriano Mulero
标识
DOI:10.1016/j.it.2020.10.006
摘要
Hematopoiesis is a complex process through which immature bone marrow precursor cells mature into all types of blood cells. Although the association of hematopoietic lineage bias (including anemia and neutrophilia) with chronic inflammatory diseases has long been appreciated, the causes involved are obscure. Recently, cytosolic multiprotein inflammasome complexes were shown to activate inflammatory and immune responses, and directly regulate hematopoiesis in zebrafish models; this was deemed to occur via cleavage and inactivation of the master erythroid transcription factor GATA1. Herein summarized are the zebrafish models that are currently available to study this unappreciated role of inflammasome-mediated regulation of hematopoiesis. Novel putative therapeutic strategies, for the treatment of hematopoietic alterations associated with chronic inflammatory diseases in humans, are also proposed.
科研通智能强力驱动
Strongly Powered by AbleSci AI