河蚬
化学
纳米颗粒
功能性食品
超分子化学
食品科学
生物化学
生物
生物物理学
环境化学
纳米技术
有机化学
材料科学
分子
作者
Guanzhen Gao,Huiqin Wang,Jingran Zhou,Pingfan Rao,Ke Liu,Jing Jen Lin,Bonnie Sun Pan,Yue Zhang,Qiang Wang
标识
DOI:10.1021/acs.jafc.0c02402
摘要
Nanoparticles can be prepared by several sophisticated processes but until now, it cannot be prepared by simple home cooking. Here, we report that two incidental food nanoparticles (iFNPs) consisting of proteoglycans and phytosterols were isolated from soup made from freshwater clam (Corbicula fluminea Muller), a renowned folk remedy for liver problems in China and other parts of East Asia. These two bioactive iFNPs were obtained and characterized by anionic exchange chromatography coupled with multi-angle laser light scattering measurement. Their hydrodynamic diameters and ζ-potentials were 50 ± 0.2 nm and −28.0 mV and 67 ± 0.4 nm and −9.96 mV, respectively. FT-IR revealed that the proteoglycans in the particles contained α-type heteropolysaccharides. Both iFNPs were resistant to pH changes and separation by mechanical force but responsive to temperature changes. They effectively inhibited cholesterol uptake in vitro, which resonates with the traditional belief that freshwater clam soup provides hepatoprotective benefits. This study suggests that these two proteoglycan–lipid iFNPs are the active moieties and offers a supramolecular structure-based approach to study the function of such complex matrices derived from food.
科研通智能强力驱动
Strongly Powered by AbleSci AI