Hepatic Uptake and Biliary Excretion of Indocyanine Green in the Dog.

1. Indocyanine green given intravenously to dogs is distributed in the plasma compartment and rapidly removed by the liver. 2. Biliary excretion of the dye is delayed, but an average of 97.3% of the administered dose is eventually recovered from the bile in apparently unaltered form. Indocyanine green does not appear in the urine. 3. Indocyanine green interferes with hepatic uptake of BSP from the plasma. 4. Absorption of indocyanine green from the bowel is minimal.