Solubility,n-octanol-water and liposome-water partition coefficients of cucurbitacin E

Objective To determine the solubility of cucurbitacin E and its partition coefficients for n-octanol-water and liposome-water solution systems.Methods The solubility,partition coefficient for n-octanol-water and liposome-water were measured by equilibrium method,shaking flask and equilibrium dialysis method,respectively.Results The solubility of cucurbitacin E in water was 0.155 mg·L-1,it was cosolvent in ethanol and tertiary butyl alcohol,the partition coefficients for n-octanol-water and liposome-water were(2.088±0.054)and(0.003-1.819),respectively.Conclusions Cucurbitacin E is insoluble in water,its partition coefficients for n-octanol-water and liposome-water are moderate.