Molecular Structure and Function of Interferon Regulatory Factor-1

Interferon regulatory factor 1(IRF-1)is a important multifunctional transcription factor for regulating of expression of interferon(IFN)and having cantivirus action,antineoplastic activity.Indeed,IRF-1selectively modulates different sets of genes,depending on the cell type in order to evoke appropriate responses in each.The author summarizes the structure,the transcriptional regulation and the multiple biological effects.