Berberine modulates the immunometabolism and differentiation of CD4+ T cells alleviating experimental arthritis by suppression of M1-exo-miR155

BACKGROUND: T cells response are related to its suppression of M1 macrophage still unclear. PURPOSE: T cells are related to exosome derived from M1-macrophage (M1-exo). STUDY-DESIGN/METHODS: T cells were assessed by ECAR, OCR, and the level of glucose, lactate, intracellular ATP. RESULT: T cells induced by M1-exo, while these regulation effects were significantly weakened by miR155 mimic. CONCLUSION: T cell subsets balance, achieved by reducing the transfer of M1-exo-miR155 into T cells.