Changes in epigenetic information during the occurrence and development of gastric cancer

Gastric cancer is one of the most common malignant tumors of the digestive tract, with a high degree of malignancy and poor prognosis. With advancements in disease research, the role of epigenetic changes in its pathogenesis has become a research focus. The known epigenetic changes mainly include DNA methylation, histone modification, and regulation of chromatin structure. This article details the effects of these changes that would result in gastric cancer. Using next-generation sequencing methods and bioinformatics analysis, we can determine the epigenetic changes in abnormal tissues of the digestive tract that facilitate the early diagnosis and treatment of gastric cancer patients. In this article, we summarize how epigenetic changes determine gastric cancer and the new technologies used in research on cancer to benefit gastric cancer patients.