A Hydrogel Engineered with Semiconductive MnPSe3 Nanosheets as an Integrative Sonosensitizer/Fenton‐Like Catalyst/Nutrient for Melanoma Postoperative Care

Abstract The simultaneous inhibition of tumor recurrence and promotion of wound healing are critical for patients undergoing melanoma surgery. However, the development of an effective yet straightforward platform that meets the comprehensive therapeutic requirements of clinical melanoma postoperative care still remains a significant challenge. Herein, a 2D semiconductive MnPSe 3 nanosheets (MPS NSs)‐engineered sodium alginate (SA) hydrogel dressing (SA‐MPS) is developed. The MPS NSs, a member of the ternary transition metal phosphorous chalcogenides (TMPCs), are successfully prepared through an ultrasonic‐assisted liquid phase exfoliation approach from bulk MnPSe 3 . These nanosheets exhibit the integrative functions of sonosensitizers, Fenton‐like catalysts, glutathione (GSH) scavengers, and phosphorus (P)/selenium (Se)‐containing nutrients. In vitro and in vivo evaluations demonstrate that the SA‐MPS hydrogel dressing possesses excellent biocompatibility and is effective for combined sonodynamic/chemodynamic therapy (SDT/CDT) of tumors, with amplified reactive oxygen species (ROS) production. Additionally, it promotes skin regeneration in postoperative wounds by supplying bioactive P/Se elements. Hence, such a multifunctional SA‐MPS hydrogel dressing without complex integration offers great potential for suppressing postoperative melanoma recurrence while facilitating wound healing, making it a promising candidate for melanoma postoperative care.