循环肿瘤细胞
血小板
流固耦合
毛细管作用
生物医学工程
转移
血小板活化
材料科学
化学
有限元法
癌症
医学
内科学
物理
复合材料
热力学
作者
Marija Milošević,Vladimir Simić,Aleksandar Nikolić,Ningsheng Shao,Chihiro Hashimoto,Biana Godin,Fransisca Leonard,Xuewu Liu,Milos̆ Kojić
标识
DOI:10.1016/j.cmpb.2023.107810
摘要
We used a 2D fluid-solid interaction (FSI) model to investigate the critical conditions for the arrest of the CTCs traveling through the narrowed capillary with a platelet attached to the capillary wall. This computational model allows us to determine the deformations and the progression of the passage of the CTC through different types of microvessels with platelet included. The modeling process is obtained using the strong coupling approach following the remeshing procedure. Also, the 1D FE rope element for simulating active ligand-receptor bonds is implemented in our computational tool (described below). A relationship between the CTCs properties (size and stiffness), the platelet size and stiffness, and the ligand-receptor interaction intensity, on one side, and the time in contact between the CTCs and platelet and conditions for the cell arrest, on the other side, are determined. The model is further validated in vitro by using a microfluidic device with metastatic breast tumor cells. The computational framework that is presented, with accompanying results, can be used as a powerful tool to study biomechanical conditions for CTCs arrest in interaction with platelets, giving a prognosis of disease progression.
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