微卫星不稳定性
免疫系统
生物
癌症研究
结直肠癌
DNA错配修复
基因组不稳定性
癌症
癌症的体细胞进化
免疫检查点
遗传学
等位基因
免疫疗法
微卫星
基因
DNA
DNA损伤
作者
Yuta Kobayashi,Atsushi Niida,Satoshi Nagayama,Koichi Saeki,Hiroshi Haeno,Kazuki Takahashi,Shuto Hayashi,Yuki Ozato,Hideyuki Saito,Takanori Hasegawa,Hiromi Nakamura,Taro Tobo,Akihiro Kitagawa,Kuniaki Sato,Dai Shimizu,Hidenari Hirata,Yuichi Hisamatsu,Takeo Toshima,Yusuke Yonemura,Takaaki Masuda
标识
DOI：10.1038/s41416-023-02395-8
摘要
Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H) colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H CRCs is generated in cancer evolution and how immune selective pressure affects ITH.
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