角蛋白
伤口愈合
角质形成细胞
细胞生物学
再生(生物学)
血管生成
角蛋白6A
伤口闭合
生物
癌症研究
免疫学
中间灯丝
生物化学
遗传学
体外
细胞骨架
细胞
作者
Wenfeng Li,Rui Qing,Haojie Zhang,Ziwei Wang,Yuhan Yuan,Lili Wang,Jia Deng,Bochu Wang,Shilei Hao
标识
DOI:10.1002/adfm.202307634
摘要
Abstract Trichocyte keratins hold significant promise in accelerating wound healing. Yet it is difficult to discriminate characteristics and mechanisms from their subtypes because of the high sequence homology. Here, the distinct wound healing properties in terms of wound closure rate, epidermal regeneration and angiogenesis of 17 kinds of human hair keratins is reported. Each trichocyte keratin shows distinct behaviors with unique advantages. Amongst all, recombinant keratin (RK) 33B, RK34, RK39 and RK84 show the highest efficiency in wound closure acceleration, and RK34, RK37 and RK81 presented the strongest angiogenic performance. Furthermore, transcriptomic analysis revealed the regulatory mechanisms of trichocyte keratins in the proliferation and migration of keratinocyte and blood vessel generation. Finally, the keratins with strong re‐epithelialization and angiogenic performances significantly accelerate wound closure in a diabetic rat model established in‐house. The findings provide a panorama view of trichocyte keratin performance in wound healing and that may harbor potential for finely tailored keratin development and precision applications.
科研通智能强力驱动
Strongly Powered by AbleSci AI