CYP2C19型
单倍型
等位基因
药物遗传学
背景(考古学)
遗传学
生物
进化生物学
基因
基因型
古生物学
作者
Ross P Booyse,David Twesigomwe,Scott Hazelhurst
出处
期刊:Pharmacogenomics
[Future Medicine]
日期:2023-11-01
卷期号:24 (16): 845-857
标识
DOI:10.2217/pgs-2023-0166
摘要
Background:CYP2C19 is important in the metabolism of clopidogrel and several antidepressants. This study aimed to characterize the distribution of CYP2C19 star alleles (haplotypes) across diverse African populations compared with global populations. Methods:CYP2C19 star alleles and diplotypes were called from high coverage genomes using the StellarPGx pipeline. Results:CYP2C19*1 (51%), *2 (17%) and *17 (22%) were the most common star alleles across African populations in this study. It was observed that 3% of African participants had potentially novel CYP2C19 haplotypes. Conclusion: This study supports the necessity for CYP2C19 pharmacogenetic testing in African and global clinical settings, as well as the importance of comprehensive star allele characterization in the African context.
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