Peripheral Oxygenation and Pulmonary Hemodynamics in Individuals With Fontan Circulation During 24-Hour High-Altitude Exposure Simulation

HomeCirculationVol. 149, No. 18Peripheral Oxygenation and Pulmonary Hemodynamics in Individuals With Fontan Circulation During 24-Hour High-Altitude Exposure Simulation No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextPeripheral Oxygenation and Pulmonary Hemodynamics in Individuals With Fontan Circulation During 24-Hour High-Altitude Exposure Simulation Nicole Müller, Julian Alexander Härtel, Jan Schmitz, Ute Baur, Melanie von der Wiesche, Iris Rieger, Darius Gerlach, Jon von Stritzky, Anja Bach, Christopher Hart, Janina Bros, Benedikt Seeger, Emily Zollmann, Marijke Grau, Boris Dragutinovic, Laura-Maria de Boni, Jan-Niklas Hönemann, Wilhelm Bloch, Daniel Aeschbach, Eva-Maria Elmenhorst, Ulrike Herberg, Alena Hess, Moritz Schumann, Tobias Kratz, Jens Jordan, Johannes Breuer and Jens Tank Nicole MüllerNicole Müller https://orcid.org/0000-0001-9211-9209 Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Julian Alexander HärtelJulian Alexander Härtel https://orcid.org/0000-0003-0852-2850 Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Jan SchmitzJan Schmitz Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Germany (J.S.). , Ute BaurUte Baur Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Melanie von der WiescheMelanie von der Wiesche https://orcid.org/0000-0002-6487-2460 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Iris RiegerIris Rieger Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Darius GerlachDarius Gerlach https://orcid.org/0000-0001-7044-6065 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Jon von StritzkyJon von Stritzky https://orcid.org/0009-0007-7141-3952 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Anja BachAnja Bach Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Christopher HartChristopher Hart https://orcid.org/0000-0001-5880-3576 Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Janina BrosJanina Bros https://orcid.org/0009-0008-1014-0425 Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Benedikt SeegerBenedikt Seeger Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). , Emily ZollmannEmily Zollmann https://orcid.org/0000-0001-7137-3013 Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). , Marijke GrauMarijke Grau https://orcid.org/0000-0003-1980-9195 Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). , Boris DragutinovicBoris Dragutinovic Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). , Laura-Maria de BoniLaura-Maria de Boni https://orcid.org/0000-0001-7785-482X Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Jan-Niklas HönemannJan-Niklas Hönemann Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic III for Internal Medicine, Cologne, Germany (J.-N.H.). Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Germany (J-N.H., J.J.). , Wilhelm BlochWilhelm Bloch Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). , Daniel AeschbachDaniel Aeschbach https://orcid.org/0000-0002-6054-5753 Institute of Experimental Epileptology and Cognition Research (D.A.), University of Bonn Medical Center, Germany. Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). , Eva-Maria ElmenhorstEva-Maria Elmenhorst https://orcid.org/0000-0003-0336-6705 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). Institute for Occupational, Social and Environmental Medicine (E-M.E.), Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Germany. , Ulrike HerbergUlrike Herberg https://orcid.org/0000-0002-9386-0258 Department of Pediatric Cardiology (U.H.), Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Germany. , Alena HessAlena Hess Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Moritz SchumannMoritz Schumann Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). Department of Sports Medicine and Exercise Therapy, Institute of Human Movement Science and Health, Chemnitz University of Technology, Germany (M.S.). , Tobias KratzTobias Kratz https://orcid.org/0000-0003-3369-4494 Department of Pediatric Cardiology (N.M., J.A.H., U.B., C.H., A.H., T.K., J.B.), University of Bonn Medical Center, Germany. , Jens JordanJens Jordan https://orcid.org/0000-0003-4518-0706 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). Medical Faculty, University of Cologne, Albertus-Magnus-Platz, Cologne, Germany (J.J.). Department of Internal Medicine III, Division of Cardiology, Pneumology, Angiology, and Intensive Care, University of Cologne, Germany (J-N.H., J.J.). , Johannes BreuerJohannes Breuer https://orcid.org/0000-0001-7572-0692 Department of Molecular and Cellular Sports Medicine, German Sport University Cologne, Germany (J.B., B.S., E.Z., M.G., B.D., W.B., M.S.). and Jens TankJens Tank Correspondence to: Jens Tank, MD, Linder Hoehe, 51147 Cologne, Germany. Email E-mail Address: [email protected] https://orcid.org/0000-0002-5672-1187 Institute of Aerospace Medicine, German Aerospace Center, Cologne, Germany (J.S., M.v.d.W., I.R. D.G., J.v.S., A.B., L-M.d.B., J-N.H., D.A., E-M.E., J.J., J.T.). Originally published29 Apr 2024https://doi.org/10.1161/CIRCULATIONAHA.123.067601Circulation. 2024;149:1466–1468FootnotesRegistration: URL: https://drks.de/search/en/trial/DRKS00025989; Unique identifier: DRKS000025989.For Sources of Funding and Disclosures, see page 1468.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Jens Tank, MD, Linder Hoehe, 51147 Cologne, Germany. Email jens.tank@dlr.deREFERENCES1. Hoffmann F, Limper U, Zaha VG, Reuter H, Zange L, Schulz-Menger J, Hein M, Baldus S, Levine BD, Jordan J, et al. Evolution of pulmonary hypertension during severe sustained hypoxia.Circulation. 2020; 141:1504–1506. doi: 10.1161/CIRCULATIONAHA.119.045192LinkGoogle Scholar2. Muller N, Herberg U, Jung T, Breuer J, Hartel JA. Adequate exercise response at artificial altitude in Fontan patients.Front Pediatr. 2022; 10:947433. doi: 10.3389/fped.2022.947433CrossrefMedlineGoogle Scholar3. Staempfli R, Schmid JP, Schenker S, Eser P, Trachsel LD, Deluigi C, Wustmann K, Thomet C, Greutmann M, Tobler D, et al. Cardiopulmonary adaptation to short-term high altitude exposure in adult Fontan patients.Heart. 2016; 102:1296–1301. doi: 10.1136/heartjnl-2016-309682CrossrefMedlineGoogle Scholar4. Joseph AA, Merboldt KD, Voit D, Zhang S, Uecker M, Lotz J, Frahm J. Real-time phase-contrast MRI of cardiovascular blood flow using undersampled radial fast low-angle shot and nonlinear inverse reconstruction.NMR Biomed. 2012; 25:917–924. doi: 10.1002/nbm.1812CrossrefMedlineGoogle Scholar5. Elmenhorst EM, Rooney D, Benderoth S, Wittkowski M, Wenzel J, Aeschbach D. Sleep-induced hypoxia under flight conditions: implications and countermeasures for long-haul flight crews and passengers.Nat Sci Sleep. 2022; 14:193–205. doi: 10.2147/NSS.S339196CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate.Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page.Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetails April 30, 2024Vol 149, Issue 18 Advertisement Article InformationMetrics © 2024 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.123.067601PMID: 38683898 Originally publishedApril 29, 2024 KeywordsFontan procedurehypoxiapulmonary artery pressurepulmonary blood flowPDF download Advertisement SubjectsCongenital Heart DiseaseHeart FailureHemodynamicsMagnetic Resonance Imaging (MRI)Physiology