膜联蛋白A1
炎症
医学
疾病
药理学
功能(生物学)
生物信息学
神经科学
膜联蛋白
免疫学
生物
内科学
细胞生物学
流式细胞术
作者
Mauro Perretti,Jesmond Dalli
出处
期刊:Annual Review of Pharmacology and Toxicology
[Annual Reviews]
日期:2023-01-20
卷期号:63 (1): 449-469
被引量:16
标识
DOI:10.1146/annurev-pharmtox-051821-042743
摘要
Chronic diseases that affect our society are made more complex by comorbidities and are poorly managed by the current pharmacology. While all present inflammatory etiopathogeneses, there is an unmet need for better clinical management of these diseases and their multiple symptoms. We discuss here an innovative approach based on the biology of the resolution of inflammation. Studying endogenous pro-resolving peptide and lipid mediators, how they are formed, and which target they interact with, can offer innovative options through augmenting the expression or function of pro-resolving pathways or mimicking their actions with novel targeted molecules. In all cases, resolution offers innovation for the treatment of the primary cause of a given disease and/or for the management of its comorbidities, ultimately improving patient quality of life. By implementing resolution pharmacology, we harness the whole physiology of inflammation, with the potential to bring a marked change in the management of inflammatory conditions.
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