化学
缺氧(环境)
肺动脉高压
肠道菌群
新陈代谢
色氨酸
药理学
内分泌学
内科学
生物化学
氧气
氨基酸
医学
有机化学
作者
Jinhao Shuai,Sheng He,Yang Wang,Junjie Zhen,Duonan Yu,Mengying Lv
标识
DOI:10.1016/j.jpba.2025.117111
摘要
Pulmonary hypertension (PH) is a life-threatening disease, mainly caused by pulmonary arterial inflammation and remodeling, which resulted in elevated pulmonary arterial pressure (PAP) and ultimate rightsided heart failure. In the present study, Wistar rats were exposed to hypoxia for four weeks to induce PH. Multiomics approaches integrating 16S rRNA sequencing, untargeted and targeted metabolomics were utilized to identify alterations in gut microbiota and host metabolism associated with hypoxia-induced pulmonary hypertension. Rats exposed to hypoxia for four weeks exhibited the increased right ventricular systolic pressure (RVSP), pulmonary vascular remodeling, right ventricular hypertrophy, gut microbiota dysbiosis and disturbed serum metabolism. Tryptophan-pathway targeted metabolomics showed that chronic hypoxia exposure induced an increase of tryptophan, xanthurenic acid and 3-indoleacetic acid levels and a decrease of kynurenine, nicotinamide and kynurenic acid levels. Our research would offer promising targets for early diagnosis and treatment of PH.
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