海马结构
海马体
空间记忆
神经科学
空间认知
编码(社会科学)
路径集成
空间分析
生物
计算机科学
预测编码
空间生态学
认知
地理
数学
工作记忆
统计
遥感
生态学
作者
Jiali Liu,Dong Chen,Xiao Xue,Hui Zhang,Wenjing Zhou,Shuli Liang,Lukas Kunz,Andreas Schulze‐Bonhage,Nikolai Axmacher,Liang Wang
出处
期刊:Current Biology
[Elsevier]
日期:2023-05-01
卷期号:33 (10): 2024-2033.e3
被引量:3
标识
DOI:10.1016/j.cub.2023.04.033
摘要
Goal-directed navigation relies on both coarse and fine-grained coding of spatial distance between the current position of a navigating subject and a goal destination. However, the neural signatures underlying goal distance coding remain poorly understood. Using intracranial EEG recordings from the hippocampus of drug-resistant epilepsy patients who performed a virtual spatial navigation task, we found that the right hippocampal theta power was significantly modulated by goal distance and decreased with goal proximity. This modulation varied along the hippocampal longitudinal axis such that theta power in the posterior hippocampus decreased more strongly with goal proximity. Similarly, neural timescale, reflecting the duration across which information can be maintained, increased gradually from the posterior to anterior hippocampus. Taken together, this study provides empirical evidence for multi-scale spatial representations of goal distance in the human hippocampus and links the hippocampal processing of spatial information to its intrinsic temporal dynamics.
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