アップコンバージョンナノ粒子を用いた双安定型オプシンOPN5の近赤外光による制御

Optogenetics enables precise regulation of cellular functions through the genetic introduction of light-responsive proteins and optical stimulation.Conventional optogenetic approaches predominantly rely on ultraviolet (UV) or visible light, which suffer from limited tissue penetration and high phototoxicity, thereby restricting non-invasive and deep-tissue applications.Upconversion nanoparticles (UCNPs), capable of converting near-infrared (NIR) light into higher-energy UV and visible emission, provide a promising strategy to overcome these limitations by exploiting the superior tissue penetration and low phototoxicity of NIR light.