Real-world safety signals of isoniazid in adults and children: a complementary FAERS analysis to inform paediatric dose optimisation

Extract We read with great interest the individual participant data meta-analysis (IPD-MA) by Béranger et al. [1], which provides robust evidence supporting the World Health Organization-recommended isoniazid dosing regimen in children with drug-susceptible tuberculosis (TB), and elegantly demonstrates that pharmacokinetic target attainment is heavily modified by N-acetyltransferase 2 (NAT2) acetylator status and body mass index-for-age Z-score.