树枝状大分子
结合
药品
化学
药物输送
组合化学
药代动力学
毒品携带者
分子
生物物理学
立体化学
有机化学
药理学
医学
生物
数学分析
数学
作者
Zhuxian Zhou,Xinpeng Ma,Caitlin J. Murphy,Erlei Jin,Qihang Sun,Youqing Shen,Edward A. Van Kirk,William J. Murdoch
标识
DOI:10.1002/anie.201406442
摘要
Abstract The structural preciseness of dendrimers makes them perfect drug delivery carriers, particularly in the form of dendrimer–drug conjugates. Current dendrimer–drug conjugates are synthesized by anchoring drug and functional moieties onto the dendrimer peripheral surface. However, functional groups exhibiting the same reactivity make it impossible to precisely control the number and the position of the functional groups and drug molecules anchored to the dendrimer surface. This structural heterogeneity causes variable pharmacokinetics, preventing such conjugates to be translational. Furthermore, the highly hydrophobic drug molecules anchored on the dendrimer periphery can interact with blood components and alter the pharmacokinetic behavior. To address these problems, we herein report molecularly precise dendrimer–drug conjugates with drug moieties buried inside the dendrimers. Surprisingly, the drug release rates of these conjugates were tailorable by the dendrimer generation, surface chemistry, and acidity.
科研通智能强力驱动
Strongly Powered by AbleSci AI