阿尔戈瑙特
生物
小RNA
心理压抑
遗传学
翻译(生物学)
核糖核酸
基因
RNA干扰
小RNA
基因表达调控
非编码RNA
基因表达
计算生物学
细胞生物学
信使核糖核酸
作者
Allison C. Mallory,Taline Elmayan,Hervé Vaucheret
标识
DOI:10.1016/j.pbi.2008.06.008
摘要
MicroRNAs are endogenously produced 21-nt riboregulators that associate with ARGONAUTE (AGO) proteins to direct mRNA cleavage or repress translation of complementary RNAs. In addition to protein-coding gene repression, miRNA-directed regulation of non-protein-coding transcripts can incite production of trans-acting siRNA (tasiRNA) populations that themselves direct mRNA repression. Arabidopsis encodes 10 AGO proteins among which, AGO1, AGO7, and AGO10 have been implicated in miRNA-guided gene repression in vivo. Recent work has shown that AGO proteins discriminate their associated small RNA populations on the basis of size and 5'-terminal nucleotide identity, extending the roles of AGO proteins beyond small RNA action. Our expanding appreciation of miRNA-directed regulation during plant development and stress adaptations has placed miRNAs at the forefront of plant biology.
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