大麻酚
大麻酚
微粒体
化学
雄烯二酮
大麻素
睾酮(贴片)
酶
雌酮
药理学
芳香化酶
内分泌干扰物
四氢大麻酚
内分泌系统
生物化学
内分泌学
内科学
生物
雄激素
大麻
激素
受体
医学
癌症
精神科
乳腺癌
作者
Kazuhito Watanabe,Erina Motoya,Naoki Matsuzawa,Tatsuya Funahashi,Toshiyuki Kimura,Tamihide Matsunaga,Koji Arizono,Ikuo Yamamoto
出处
期刊:Toxicology
[Elsevier]
日期:2005-01-01
卷期号:206 (3): 471-478
被引量:49
标识
DOI:10.1016/j.tox.2004.08.005
摘要
The progesterone 17alpha-hydroxylase activity, which is one of the steroidogenic enzymes in rat testis microsomes, was significantly inhibited by crude marijuana extracts from Delta(9)-tetrahydrocannabinolic acid (THCA)- and cannabidiolic acid (CBDA)-strains. Delta(9)-Tetrahydrocannabinol, cannabidiol and cannabinol also inhibited the enzymatic activity with relatively higher concentration (100-1000 microM). Testosterone 6beta- and 16alpha-hydroxylase activities together with androstenedione formation from testosterone in rat liver microsomes were also significantly inhibited by the crude marijuana extracts and the cannabinoids. Crude marijuana extracts (1 and 10 microg/ml) of THCA strain stimulated the proliferation of MCF-7 cells, although the purified cannabinoids (THC, CBD and CBN) did not show significant effects, such as the extract at the concentration of 0.01-1000 nM. These results indicate that there are some metabolic interactions between cannabinoid and steroid metabolism and that the constituents showing estrogen-like activity exist in marijuana.
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