生物
神经嵴
颅面
脊椎动物
形态发生
颅神经嵴
解剖
进化生物学
神经科学
细胞生物学
遗传学
胚胎
基因
作者
Maryline Minoux,Filippo M. Rijli
出处
期刊:Development
[The Company of Biologists]
日期:2010-08-15
卷期号:137 (16): 2605-2621
被引量:366
摘要
During vertebrate craniofacial development, neural crest cells (NCCs) contribute much of the cartilage, bone and connective tissue that make up the developing head. Although the initial patterns of NCC segmentation and migration are conserved between species, the variety of vertebrate facial morphologies that exist indicates that a complex interplay occurs between intrinsic genetic NCC programs and extrinsic environmental signals during morphogenesis. Here, we review recent work that has begun to shed light on the molecular mechanisms that govern the spatiotemporal patterning of NCC-derived skeletal structures – advances that are central to understanding craniofacial development and its evolution.
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