脂肪组织
炎症
脱颗粒
免疫系统
脂肪细胞
趋化因子
脂肪因子
生物
免疫学
肥大细胞
脂肪组织巨噬细胞
成纤维细胞
纤维化
结缔组织
细胞生物学
白色脂肪组织
医学
内科学
内分泌学
瘦素
肥胖
细胞培养
受体
遗传学
作者
Paulina Żelechowska,Justyna Agier,Elżbieta Kozłowska,Ewa Brzezińska‐Błaszczyk
摘要
Obesity is reckoned as one of the civilization diseases, posing a considerable global health issue. Evidence points towards a contribution of multitude immune cell populations in obesity pathomechanism and the development of chronic low-grade inflammation in the expanded adipose tissue. Notably, adipose tissue is a reservoir of mast cells which number in individuals with obesity particularly increased. Some of them tend to degranulation what generate secretion of strong pro-inflammatory and regulatory mediators, as well as cytokines/chemokines. Several lines of evidence suggest that mast cells are strictly associated with pro-inflammatory status in adipose tissue by their indirect impact on immune cell attraction and activation. Furthermore, mast cells affect adipose tissue remodelling and fibrosis by adipocyte differentiation, fibroblast proliferation and enhancing extracellular matrix proteins expression. This review will summarize current knowledge on mast cell features and their role in the development of chronic low-grade inflammation within adipose tissue.
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