The effect of dissolved oxygen (DO) concentration on acute toxicity of cadmium to the mummichog, Fundulus heteroclitus (L.), at selected salinities was studied. Fish were acclimated to either test salinities (10, 20, 32 ‰) or to 32 ‰ and then exposed at 10 and 20 ‰. Levels of DO between 4 mg/liter and saturation did not significantly influence the tolerance of fish to cadmium poisoning in 96 hours, regardless of salinity and acclimation regime.