Peroxidase‐Mimicking Nanozyme with Enhanced Activity and High Stability Based on Metal–Support Interactions

Abstract Peroxidase‐mimicking nanozymes offer unique advantages in terms of high stability and low cost over natural peroxidase for applications in bioanalysis, biomedicine, and the treatment of pollution. However, the design of high‐efficiency peroxidase‐mimicking nanozymes remains a great challenge. In this study, we adopted a structural‐design approach through hybridization of cube‐CeO2 and Pt nanoparticles to create a new peroxidase‐mimicking nanozyme with high efficiency and excellent stability. Relative to pure cube‐CeO2 and Pt nanoparticles, the as‐hybridized Pt/cube‐CeO2 nanocomposites display much improved activities because of the strong metal–support interaction. Meanwhile, the nanocomposites also maintain high catalytic activity after long‐term storage and multiple recycling. Based on their excellent properties, Pt/cube‐CeO2 nanocomposites were used to construct high‐performance colorimetric biosensors for the sensitive detection of metabolites, including H2O2 and glucose. Our findings highlight opportunities for the development of high‐efficiency peroxidase‐mimicking nanozymes with potential applications such as diagnostics, biomedicine, and the treatment of pollution.